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A molecular understanding of alphavirus entry
Autumn C Holmes1, Katherine Basore2, Daved H Fremont2,3,4,5
1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Abstract:
Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway, including attachment, internalization, and fusion. Herein, we review recent developments in the molecular understanding of alphavirus entry both in vitro and in vivo and how these advances might enable the design of therapeutics targeting this critical step in the alphavirus life cycle.
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