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Updated: Dec 4, 2025
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Lignin-based fluorescence hollow nanoparticles: Their preparation, characterization, and encapsulation properties for
Yu Zhou1, Yanming Han2, Gaiyun Li2
1Research Institute of Wood Industry, Chinese Academy of Forestry, Xiangshan Road, Beijing 100089, China; School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Jianjun East Road, Yancheng 224051, China; Jiangsu Province Biomass Energy and Materials Laboratory, Institute of Chemical Industry of Forest Products, Longpan Road, Nanjing 210042, China.
Abstract:
Lignin shows strong adsorption, biodegradability and non-toxicity, and has opened a research hotspot in the design and manufacture of controllable nanomaterials for drug delivery. However, lignin-based materials, with both diagnostic and therapeutic functions, have yet to be developed. In this work, enzymatically hydrolysable lignin (EHL) was used to prepare blue fluorescent lignin copolymer by grafting 1-Pyrenebutyric acid onto lignin via amidation reaction and then formed self-assembled nanoparticles. The results show that such lignin-based hollow nanoparticles exhibit characteristics of fluorescent functions, size controlled and stable structure within 15 days. For anticancer drug Doxorubicin, the encapsulation efficiency and drug loading reached, respectively, 50% and 10%. This encapsulation had no cytotoxicity, and sustained-release effect on the drug. The aim of this study was to develop the multifunctional bio-nanomaterials for medical applications, through simple, environmentally friendly, low-cost methods.
