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Related Experiment Video

Updated: Dec 4, 2025

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

Discrepancies in Assessing Diastolic Function in Pre-Clinical Heart Failure Using Different Algorithms-A Primary Care

Martina Setti¹, Giovanni Benfari¹, Donato Mele²

¹Division of Cardiology, Department of Medicine, University of Verona, 37126 Verona, Italy.

Diagnostics (Basel, Switzerland)

|October 23, 2020

Summary

Current diastolic function guidelines show inconsistencies. The left atrial volume index/late diastolic a'-ratio (LAVi/a') effectively resolves indeterminate diagnoses in echocardiography.

Keywords:

diastole echocardiography guidelines pre-clinical heart failure primary care

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

Area of Science:

Cardiology
Echocardiography
Diastology

Background:

Current guidelines for diastolic function (DF) assessment by ASE/EACVI face disputes.
Two alternative algorithms by Johansen et al. and Oh et al. have been proposed.
This study compares ASE/EACVI guidelines with these alternative approaches.

Purpose of the Study:

Assess concordance between ASE/EACVI guidelines and alternative DF assessment methods.
Evaluate the prevalence of indeterminate diastolic dysfunction (DD) using each method.
Identify strategies to reduce indeterminate DD diagnoses.

Main Methods:

Retrospective analysis of 1158 echocardiographic reports.
Calculation of concordance using k coefficient and DD reclassification rate.
Assessment of pulmonary vein flow (PVF), Valsalva maneuver, and LAVi/a' for indeterminate grading.

Main Results:

Significant discordance observed between all compared methods (p < 0.0001).
DD reclassification rates ranged from 30.1% to 36.5%.
LAVi/a' proved most effective in resolving indeterminate diagnoses, followed by PVF and Valsalva maneuver.

Conclusions:

Inconsistencies among DF assessment guidelines limit clinical interchangeability.
Conventional echocardiography, particularly LAVi/a', can resolve most inconclusive diagnoses.
LAVi/a' offers a simple and effective method for improving diastolic dysfunction grading.