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Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy

Jiaqi Li1, Jie Qing Eu2, Li Ren Kong2,3

  • 1School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.

Molecules (Basel, Switzerland)
|October 23, 2020
PubMed

Insights

Targeting cancer

Area of Science:

  • Oncology
  • Cancer Metabolism

Background:

  • Tumor metabolism reprogramming is a hallmark of cancer.
  • Metabolic differences between cancer and normal cells offer therapeutic targets.
  • Tumor microenvironment interactions create complex metabolic networks.

Purpose of the Study:

  • To review therapeutic opportunities arising from altered tumor metabolism.
  • To highlight metabolic crosstalk within the tumor microenvironment.
  • To focus on precision targeting and combinatorial strategies.

Main Methods:

  • Literature review of cancer metabolism and tumor microenvironment interactions.
  • Analysis of metabolic reprogramming in malignancy.
  • Discussion of therapeutic strategies targeting metabolic pathways.

Main Results:

  • Metabolic reprogramming creates exploitable vulnerabilities in cancer cells.
  • Crosstalk between cancer cells and stromal components influences tumor progression.
  • Targeting metabolic networks can impact proliferation, metastasis, and treatment resistance.

Conclusions:

  • Altered tumor metabolism presents significant therapeutic opportunities.
  • Understanding metabolic crosstalk is crucial for effective cancer treatment.
  • Combinatorial strategies offer promise for precision targeting of tumor metabolism.
Keywords:
cancer cell metabolismimmunotherapymetabolic reprogrammingtargeted therapytumour microenvironment

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