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Chemical constituents from the branches and leaves of Alchornea annamica
Nguyen Huu Toan Phan1, Nguyen Thi Dieu Thuan1, Nguyen Thi Thu Hien1
1Tay Nguyen Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), Dalat, Vietnam.
Abstract:
Phytochemical investigation of the branches and leaves of Alchornea annamica led to isolation of ten secondary metabolites, including two new megastigmane glucosides alnamicosides A (1) and B (2). The structure elucidation was confirmed by 1 D and 2 D NMR, ECD as well as HR-QTOF-MS experiments. The megastigmane derivatives 1 - 3 exhibited inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC50 values of 78.72 ± 1.90, 77.40 ± 9.40 and 82.16 ± 4.56 µM, respectively. This is the first report on chemical constituents and biological activity of the plant A. annamica.
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