Related Experiment Video

Updated: Dec 4, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.2K

Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19

Jiwon Kim1, Alexander Volodarskiy2, Razia Sultana3

  • 1Division of Cardiology, Weill Cornell Medicine, New York, New York; Department of Radiology, Weill Cornell Medicine, New York, New York.

Journal of the American College of Cardiology
|October 23, 2020
PubMed

Insights

Right ventricular remodeling, including dysfunction and dilation, independently predicts mortality in COVID-19 patients. This finding offers crucial prognostic insights beyond existing clinical and biomarker assessments for coronavirus disease 2019.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with an increased risk of right ventricular (RV) dysfunction and dilation.
  • The prognostic significance of adverse RV remodeling in COVID-19 patients remains unclear.

Purpose of the Study:

  • To determine if adverse RV remodeling (dysfunction/dilation) predicts COVID-19 prognosis independently of established clinical and biomarker risk factors.
  • To assess the independent prognostic utility of RV remodeling in hospitalized COVID-19 patients.

Main Methods:

  • A study of 510 consecutive COVID-19 inpatients across three New York City hospitals.
  • Transthoracic echocardiography images were centrally analyzed by a core laboratory blinded to clinical and biomarker data.
  • Assessment of RV dilation and dysfunction, and correlation with inpatient mortality and hospital discharge.

Main Results:

  • 35% of patients exhibited RV dilation and 15% showed RV dysfunction.
  • RV dysfunction and dilation independently predicted mortality (HR: 2.57 and 1.43, respectively).
  • Adverse RV remodeling provided additional risk stratification beyond biomarkers, with the highest mortality risk in patients with both RV remodeling and positive biomarkers.

Conclusions:

  • Adverse right ventricular remodeling is an independent predictor of mortality in COVID-19 patients.
  • Echocardiographic assessment of RV remodeling offers prognostic value beyond standard clinical and biomarker evaluations.
  • These findings highlight the importance of evaluating RV status in COVID-19 management.
Abstract

Keywords:
COVID-19 (coronavirus)echocardiographyright ventricle

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