Related Experiment Video
Updated: Dec 4, 2025
Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
Published on: October 27, 2020
Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression
Ga-In Lee1, Ki Young Son1, Kyung-Ah Park2
1From the Department of Ophthalmology (G.-I.L., K.Y.S., K.-A.P., S.Y.O.) and Department of Neurosurgery, Endoscopic Skull Base Surgery Clinic, Brain Tumor Center (D.-S.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Objective:
To test the hypothesis that there was a temporal change in the retinal microstructure after decompression surgery for chiasmal compression, the 1-year longitudinal changes in the inner and outer retinal thickness after decompression surgery were analyzed using spectral-domain optical coherence tomography (SD-OCT) with linear mixed-effects models.
Methods:
SD-OCT was obtained from 87 eyes with chiasmal compression and compared to 100 healthy controls. The preoperative and 1-year postoperative longitudinal changes in the retinal layer thickness were measured. The thickness of each of the following retinal layers was analyzed: the macular retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, and the photoreceptor layer.
Results:
The RNFL, GCL, and IPL showed thinning at a rate of 1.068 μm/y (95% confidence interval [CI], 0.523, 1.613), 1.189 μm/y (95% CI 0.452, 1.925), and 1.177 μm/y (95% CI 0.645, 1.709), respectively, after decompression surgery. The preoperative thickness of the intraretinal layer was associated with postoperative visual field recovery (RNFL, odds ratio [OR] 1.221, 95% CI 1.058, 1.410; GCL, OR 1.133, 95% CI 1.024, 1.254; and IPL, OR 1.174, 95% CI 1.002, 1.376).
Conclusions:
The changes in retinal microstructure persisted and progressed in eyes with chiasmal compression after decompression surgery. The findings provide insight into the biological and anatomical sequelae following chiasmal compression. The preoperative thickness of the inner retinal layers was associated with postoperative visual field recovery.
