Hyperglycemia and arterial stiffness across two generations
Soumia Taimour1,2, Anders Gottsäter1,2, Amra Jujic2,3
1Department of Vascular Diseases.
Journal of Hypertension
|October 23, 2020
Summary
Hyperglycemia impacts arterial stiffness, particularly in older generations. Diabetes mellitus is linked to increased arterial stiffness in both parents and children, suggesting early vascular aging effects.
Area of Science:
- Cardiovascular Health
- Metabolic Disorders
- Aging Research
Background:
- Arterial stiffness is a marker of cardiovascular aging.
- Hyperglycemia and diabetes mellitus are known risk factors for cardiovascular disease.
- Understanding the generational impact of glucose metabolism on vascular health is crucial.
Purpose of the Study:
- To investigate the association between hyperglycemia and arterial stiffness across two generations.
- To determine if glucose metabolism markers correlate with arterial stiffness in parents and their children.
- To explore the influence of diabetes mellitus on arterial stiffness in a population-based cohort.
Main Methods:
- Utilized data from 2640 participants in the Malmö Offspring Study (parents and children).
- Measured arterial stiffness via carotid-femoral pulse wave velocity.
- Analyzed associations with glucose metabolism markers (fasting glucose, HbA1c) using linear regressions and t-tests, adjusting for confounders.
Main Results:
- Arterial stiffness was significantly associated with glucose and HbA1c in the total cohort and the parental generation.
- No significant association was found with skin autofluorescence.
- Participants with diabetes mellitus showed significantly higher pulse wave velocity in both generations.
Conclusions:
- Impaired glucose metabolism is linked to arterial stiffness, especially in the parental generation, highlighting hyperglycemia's role in vascular aging.
- Diabetes mellitus negatively affects arterial stiffness even in younger individuals, indicating potential for early-onset vascular changes.
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