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Updated: Dec 4, 2025
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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Recognizing and treating autosomal dominant polycystic kidney disease
1Chigozie G. Uko is an NP at GA Nephrology, Lawrenceville, Ga.
The Nurse Practitioner
|October 23, 2020
Summary
Autosomal dominant polycystic kidney disease (ADPKD) causes kidney failure. Nurse practitioners (NPs) can help patients manage ADPKD symptoms and delay the need for dialysis.
Area of Science:
- Nephrology
- Genetics
- Internal Medicine
Background:
- Autosomal dominant polycystic kidney disease (ADPKD) is a primary genetic cause of chronic kidney disease (CKD).
- ADPKD leads to progressive cyst formation, enlargement, and kidney failure, often resulting in end-stage renal disease (ESRD).
Purpose of the Study:
- To highlight the role of nurse practitioners (NPs) in managing ADPKD.
- To emphasize strategies for symptom management and delaying disease progression in ADPKD patients.
Main Methods:
- This abstract discusses the pathophysiology of ADPKD and the potential impact of NP interventions.
- It reviews current understanding of cystogenesis and kidney enlargement in ADPKD.
Main Results:
- ADPKD is characterized by cyst production, multiplication, and enlargement, leading to significant kidney volume increase.
- These pathological changes ultimately result in kidney failure and the need for renal replacement therapy.
Conclusions:
- While no cure for ADPKD exists, NPs play a crucial role in patient care.
- NPs can implement management strategies to alleviate symptoms and postpone the progression to kidney failure and dialysis.
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