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Published on: December 14, 2012
Masked Hypertension: Lessons for the Future
Krishnam R Penmatsa1,2,3, Mohan Biyani1,2,3, Ankur Gupta1,2,3
1Krishnam R. Penmatsa: MD, DM: Consultant Nephrology, Indus Hospital, Vishakhapatnam, India.
Insights
Masked hypertension (MH) is often missed but carries significant cardiovascular risks. Accurate diagnosis using out-of-office monitoring is crucial for timely intervention and improved patient outcomes.
Area of Science:
- Cardiology
- Hypertension Research
Background:
- Masked hypertension (MH) is an underdiagnosed condition.
- It presents with normal clinic blood pressure but elevated out-of-office readings.
- MH is linked to lifestyle and stress responses.
Purpose of the Study:
- To review current evidence on masked hypertension.
- To cover its definition, mechanisms, risk factors, and management.
- To highlight clinical implications and screening strategies.
Main Methods:
- Review of current evidence-based perspectives.
- Discussion of pathological mechanisms and risk factors.
- Analysis of diagnostic methods like ambulatory blood pressure monitoring.
Main Results:
- MH is a distinct hypertensive phenotype.
- It requires out-of-office monitoring for diagnosis.
- MH carries substantial cardiovascular and mortality risks.
Conclusions:
- Masked hypertension is a critical clinical concern.
- Early detection and management are essential.
- Further research into MH mechanisms and treatment is warranted.
Abstract:
Masked hypertension (MH) is a commonly overlooked phenotype of hypertension in practice. Lifestyle factors and conditioned stress response specific to out of clinic blood pressure readings may be the mechanisms leading to this phenomenon. 24-hour ambulatory blood pressure monitoring or home blood pressure monitoring in an out of office setting are required for its reliable diagnosis. MH has a high risk of progressing to sustained hypertension with comparable cardiovascular and mortality risk. In this review, we discuss current evidence-based perspectives on definition, pathological mechanisms, risk factors, screening, clinical implications, and treatment of MH.
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