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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Genetic Aspects in Shoulder Disorders.

Carina Cohen1, Eduardo A Figueiredo1, Paulo S Belangero1

  • 1Disciplina de Medicina do Esporte e Atividade Física , Centro de Traumatologia do Esporte, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Revista Brasileira De Ortopedia
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PubMed
Summary

Genetic factors influence shoulder disorders like rotator cuff injury. Building a genetic marker database may aid in predicting disease risk and developing better diagnostics and treatments.

Keywords:
gene expressiongenetic polymorphismshoulder

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Area of Science:

  • Orthopedics
  • Genetics
  • Molecular Biology

Background:

  • Genetic inheritance is increasingly studied in shoulder disorders, including rotator cuff injury, instability, and frozen shoulder.
  • Current genetic findings offer initial insights but require further development for clinical application.

Purpose of the Study:

  • To review and update the evidence of genetic studies for shoulder disorders.
  • To highlight the importance of building a genetic marker database for disease prediction and improved diagnostics/therapeutics.

Main Methods:

  • Analysis of genetic polymorphism.
  • Examination of candidate gene expression in affected tissues.
  • Review of genome-wide association studies (GWAS).

Main Results:

  • Genetic studies have explored various aspects of shoulder disorder etiology.
  • Challenges in replicating findings due to low statistical power and high false-positive rates were noted.

Conclusions:

  • Further research is needed to establish robust genetic markers for shoulder disorders.
  • A comprehensive genetic database is crucial for advancing prediction, diagnosis, and treatment strategies.