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Related Experiment Video

Updated: Dec 4, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic sclerosis in pregnancy.

Kristina En Clark¹, Oseme Etomi², Voon H Ong¹

¹Centre of Rheumatology and Connective Tissue Diseases, UCL Royal Free Medical School, London, UK.

Obstetric Medicine

|October 23, 2020

Summary

This summary is machine-generated.

Systemic sclerosis (SSc) in pregnancy requires specialized multidisciplinary care. Early optimization and vigilant management are crucial for improving outcomes for both mother and baby.

Keywords:

High-risk pregnancy perinatal medicine rheumatology systemic sclerosis

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Area of Science:

Rheumatology
Obstetrics
Maternal-Fetal Medicine

Background:

Systemic sclerosis (SSc) is a rare, multisystem connective tissue disease predominantly affecting women.
Key manifestations include skin fibrosis and Raynaud's phenomenon, with potential for severe organ involvement (lung, heart, kidney).
Pregnancy in women with SSc presents significant risks to both maternal and fetal health.

Purpose of the Study:

To review the risks of systemic sclerosis during pregnancy.
To provide management advice for healthcare professionals caring for pregnant women with SSc.
To emphasize the importance of preconception optimization and ongoing surveillance.

Main Methods:

This is a review article.
It synthesizes current knowledge on SSc and pregnancy.
It focuses on clinical manifestations, risks, and management strategies.

Main Results:

Pregnancy exacerbates SSc risks, including new or worsening organ dysfunction.
Maternal organ involvement (ILD, PAH, renal crises) increases risks significantly.
Fetal risks include prematurity and potential complications related to maternal disease activity.

Conclusions:

Preconception counseling and optimization are vital for successful pregnancy outcomes in SSc patients.
Care requires a specialized multidisciplinary team approach.
Close monitoring and management are essential throughout pregnancy and postpartum.