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Updated: Dec 4, 2025
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Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research
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PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery
Gail P Risbridger1,2,3, Mitchell G Lawrence1,2,3, Renea A Taylor2,3,4
1Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute Cancer Program, Monash University, Melbourne, Victoria, Australia.
Journal of the Endocrine Society
|October 23, 2020
Summary
Patient-derived xenografts (PDXs) are crucial for preclinical cancer research and drug development. This review explores their evolution into versatile tools that inform clinical practice guidelines.
Area of Science:
- Oncology
- Endocrinology
- Translational Research
Background:
- Patient-derived xenografts (PDXs) are widely utilized in biomedical research.
- PDXs are essential for preclinical drug testing and development, particularly in oncology.
- Extensive PDX collections have been established across various tumor types.
Purpose of the Study:
- To review the evolution of PDXs as research resources.
- To examine the role of PDXs in informing clinical practice.
- To provide evidence supporting the use of PDXs in research and healthcare.
Main Methods:
- Literature review of PDX applications.
- Analysis of PDX collection growth and diversity.
- Examination of PDX impact on drug development and clinical guidelines.
Main Results:
- PDXs have become versatile tools across multiple scientific disciplines.
- PDX models are increasingly used for personalized medicine approaches.
- Evidence supports the utility of PDXs in guiding clinical decisions.
Conclusions:
- PDXs are indispensable for advancing cancer research and drug discovery.
- The continued development and application of PDXs are crucial for improving patient outcomes.
- PDX research provides a strong foundation for evidence-based clinical practice changes.
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