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Updated: Dec 4, 2025
Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research
Published on: May 5, 2021
PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery
Gail P Risbridger1,2,3, Mitchell G Lawrence1,2,3, Renea A Taylor2,3,4
1Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute Cancer Program, Monash University, Melbourne, Victoria, Australia.
Abstract:
Patient-derived xenografts (PDXs) are tools of the trade for many researchers from all disciplines and medical specialties. Most endocrinologists, and especially those working in oncology, commonly use PDXs for preclinical drug testing and development, and over the last decade large collections of PDXs have emerged across all tumor streams. In this review, we examine how the field has evolved to include PDXs as versatile resources for research discoveries, providing evidence for guidelines and changes in clinical practice.
Insights
Patient-derived xenografts (PDXs) are crucial for preclinical cancer research and drug development. This review explores their evolution into versatile tools that inform clinical practice guidelines.
Area of Science:
- Oncology
- Endocrinology
- Translational Research
Background:
- Patient-derived xenografts (PDXs) are widely utilized in biomedical research.
- PDXs are essential for preclinical drug testing and development, particularly in oncology.
- Extensive PDX collections have been established across various tumor types.
Purpose of the Study:
- To review the evolution of PDXs as research resources.
- To examine the role of PDXs in informing clinical practice.
- To provide evidence supporting the use of PDXs in research and healthcare.
Main Methods:
- Literature review of PDX applications.
- Analysis of PDX collection growth and diversity.
- Examination of PDX impact on drug development and clinical guidelines.
Main Results:
- PDXs have become versatile tools across multiple scientific disciplines.
- PDX models are increasingly used for personalized medicine approaches.
- Evidence supports the utility of PDXs in guiding clinical decisions.
Conclusions:
- PDXs are indispensable for advancing cancer research and drug discovery.
- The continued development and application of PDXs are crucial for improving patient outcomes.
- PDX research provides a strong foundation for evidence-based clinical practice changes.
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