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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Establishing a service to tackle problematic polypharmacy.

Frances Bennett¹, Neha Shah¹, Robin Offord¹

¹University College London Hospital NHS Foundation Trust, London, UK.

Future Healthcare Journal

|October 23, 2020

Summary

A pilot secondary care clinic reduced medication burden for patients with polypharmacy, leading to fewer adverse drug reactions (ADRs) and significant cost savings. This intervention shows promise for improving patient care.

Keywords:

Polypharmacy clinical pharmacology deprescriptions medicines optimisation rational therapeutics

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Area of Science:

Pharmacology
Geriatric Medicine
Patient Safety

Background:

Polypharmacy is a growing concern, increasing the risk of adverse drug reactions (ADRs) and hospital admissions.
It negatively impacts functional status and quality of life.
Current interventions primarily focus on primary care, suggesting a need for secondary care involvement.

Purpose of the Study:

To pilot a secondary care-based polypharmacy clinic.
To assess the impact of deprescribing on ADRs and patient outcomes.
To evaluate potential cost savings associated with medication reduction.

Main Methods:

A pilot clinic was established in secondary care, led by clinical pharmacologists and pharmacists.
Medicines were deprescribed based on clinical need and suspected ADRs.
Adverse drug reaction symptom burden was measured before and after the intervention.

Main Results:

The study reviewed 24 patients, reducing their medication count by a median of 4 drugs.
Annual savings of £4,957.44 were achieved through deprescribing.
Median ADR burden decreased from 15 to 7 following the intervention.

Conclusions:

The pilot polypharmacy clinic demonstrated potential for clinical improvement and cost savings.
This model of care could be expanded to enhance outcomes for patients with polypharmacy.
Integration and sustainability of such services are recommended for improved patient care.