High-Sensitive c-Reactive Protein Levels in Euthymic Bipolar Patients: Case-Control Study.
Ghada Hamdi1,2, Hanen Ben Ammar3,4, Emira Khelifa5
1Faculty of Medicine of Tunis, El Manar University, Tunis, Tunisia. ghadaest10@gmail.com.
The Psychiatric Quarterly
|October 23, 2020
Summary
Bipolar disorder patients in remission show higher high-sensitivity C-reactive protein (hs-CRP) levels, indicating a link to chronic inflammation. This suggests anti-inflammatory treatments may benefit bipolar disorder management.
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Bipolar disorder is a chronic mental health condition.
- The immune-inflammatory system's role in bipolar disorder is under investigation.
- Chronic inflammation may contribute to the pathophysiology of bipolar disorder.
Purpose of the Study:
- To investigate plasma high-sensitivity C-reactive protein (hs-CRP) levels in bipolar disorder patients during remission.
- To compare hs-CRP levels between bipolar disorder patients and healthy controls.
Main Methods:
- A case-control cross-sectional study.
- 56 patients with bipolar disorder in clinical remission.
- 56 healthy control subjects.
Main Results:
- Mean plasma hs-CRP levels were significantly elevated in bipolar disorder patients compared to controls.
- Elevated hs-CRP in bipolar patients correlated significantly with disease severity.
Conclusions:
- Bipolar disorder is associated with a chronic inflammatory state.
- Findings suggest a potential role for anti-inflammatory therapies in managing bipolar disorder.
- Further research via randomized controlled trials is warranted to evaluate anti-inflammatory drugs.
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