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Advances in Exosomes-Based Drug Delivery Systems.
Carmen Gutierrez-Millan1,2, Clara Calvo Díaz1, José M Lanao1,2
1Area of Pharmacy and Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Salamanca, Salamanca, 37007, Spain.
Macromolecular Bioscience
|October 23, 2020
Summary
Exosomes, extracellular vesicles, offer a promising alternative to synthetic nanoparticles for targeted drug delivery, showing potential in cancer and neurological disease treatments.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cell Biology
Background:
- Exosomes are extracellular vesicles mediating intercellular communication.
- Synthetic nanoparticles face challenges with toxicity and clearance.
- Exosomes are explored as natural carriers for drug delivery systems.
Purpose of the Study:
- To analyze studies on exosome-based drug delivery systems.
- To discuss current and future applications of exosomes in drug delivery.
- To evaluate exosomes as alternatives to synthetic nanoparticles.
Main Methods:
- Literature review of exosome-based drug delivery research.
- Analysis of studies focusing on exosome applications in therapeutics.
- Synthesis of findings on exosome-mediated transport of drugs.
Main Results:
- Exosomes demonstrate potential for specific and controlled drug transport.
- Advances show promise in exosome applications for cancer therapeutics.
- Exosomes are being investigated for treating neurological diseases.
Conclusions:
- Exosomes represent a viable and advantageous platform for drug delivery systems.
- Further research is warranted to optimize exosome-based therapies.
- Exosomes offer a promising avenue for overcoming limitations of synthetic nanoparticles.
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