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Related Experiment Video

Updated: Dec 4, 2025

Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications

Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications

Published on: March 8, 2024

Not all pediatric intestinal polyps are alike.

D Vermeulen¹, M Van Winckel², S Vande Velde²

¹Pediatrics, Ghent University Hospital, Ghent, Belgium.

Acta Gastro-Enterologica Belgica

|October 23, 2020

Summary

This summary is machine-generated.

While most childhood intestinal polyps are benign, rare inherited syndromes require prompt diagnosis and management to prevent serious health risks. Early identification of genetic polyposis syndromes is crucial for reducing malignancy and mortality.

Keywords:

FAP Li Fraumeni cancer predisposition juvenile polyps polyposis syndrome

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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

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Published on: March 22, 2017

Area of Science:

Pediatric Gastroenterology
Clinical Genetics
Oncology

Background:

Intestinal polyps in children often present with painless rectal bleeding, but most are benign juvenile polyps.
Rare inherited polyposis syndromes carry a significant risk of intestinal and extra-intestinal malignancies.
Accurate diagnosis and management of these rare conditions are critical for patient outcomes.

Purpose of the Study:

To review the clinical presentation and diagnosis of intestinal polyps in pediatric patients.
To highlight the importance of identifying rare inherited polyposis syndromes.
To emphasize the need for appropriate follow-up to mitigate cancer risks.

Main Methods:

A retrospective database search of patients with intestinal polyps between 2016 and 2018.
Review of patient files for clinical manifestations and histopathology.
Literature search for red flags, genetic disorder probabilities, and diagnostic criteria for rare syndromes.

Main Results:

The study identified 30 juvenile polyps in 28 patients, along with cases of juvenile polyposis syndrome, Li Fraumeni syndrome, and familial adenomatous polyposis (FAP).
Different diagnoses have varying lifetime risks of malignancy, necessitating tailored management and surveillance strategies.
Histopathology and genetic testing are vital for diagnosing these syndromes in pediatric populations.

Conclusions:

Most childhood intestinal polyps are benign juvenile polyps requiring no specific follow-up.
Rare inherited polyposis syndromes must be considered and diagnosed to implement adequate surveillance.
Timely diagnosis and follow-up are essential for reducing morbidity and mortality associated with gastrointestinal and extraintestinal complications and malignancies.