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Related Experiment Video

Updated: Dec 4, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

EBV : not your Everyday Benign Virus.

H Ruymbeke¹, J Schouten², F Sermon³

¹Department of Gastroenterology, Ghent University, Ghent, Belgium.

Acta Gastro-Enterologica Belgica

|October 23, 2020

Summary

Epstein-Barr virus (EBV) infection, commonly causing mononucleosis, can rarely lead to spontaneous splenic rupture. Early recognition of EBV symptoms and abdominal pain is crucial for prompt diagnosis and management.

Keywords:

Epstein-Barr virus abdominal pain hepatitis splenic rupture splenomegaly

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Area of Science:

Virology
Infectious Diseases
Internal Medicine

Background:

Epstein-Barr virus (EBV) infection is highly prevalent, affecting 90% of adults.
Primary EBV infection presentations vary, often being subclinical or manifesting as infectious mononucleosis.
While typically benign, EBV can lead to severe complications.

Observation:

A 19-year-old female presented with malaise, fever, dyspnea, jaundice, vomiting, diarrhea, and left upper quadrant pain.
The patient was diagnosed with acute EBV infection, hepatitis, and splenomegaly.
She experienced a spontaneous splenic rupture.

Findings:

Spontaneous splenic rupture is a rare but life-threatening complication of infectious mononucleosis.
Acute EBV infection can present with hepatitis and significant splenomegaly, increasing rupture risk.
The case highlights the potential severity of EBV-related complications.

Implications:

Clinicians should consider spontaneous splenic rupture in EBV-suspected patients with abdominal pain.
Prompt diagnosis and management are vital for improving outcomes in EBV-related splenic rupture.
Awareness and patient counseling regarding potential EBV complications are essential.