Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Target Cell Response to Hormones01:22

Target Cell Response to Hormones

4.8K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
4.8K
Secondary Messengers in Hormone Action01:26

Secondary Messengers in Hormone Action

4.3K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
4.3K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

1.3K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.3K
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

58.0K
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
58.0K
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

5.7K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
5.7K
Types of Hormones02:13

Types of Hormones

82.5K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
82.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Change in salivary cortisol levels in children (aged 9-12 years) with obesity and respiratory diseases during a 28-day spa treatment: a pilot prospective study.

European journal of pediatrics·2026
Same author

Molecular Regulation of the CNS by Vitamin D.

Physiological research·2023
Same author

Vitamin D, a steroid hormone, from theory to practice.

Physiological research·2023
Same author

Performance of Homebalance Test in an Assessment of Standing Balance in Elderly Adults.

Physiological research·2022
Same author

Steroids, steroid associated substances and gestational diabetes mellitus.

Physiological research·2022
Same author

Endocrine risk factors for COVID-19 in context of aging.

Physiological research·2021

Related Experiment Video

Updated: Dec 4, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

2.3K

Aging, hormones and receptors.

M Hill1, Z Třískala, P Honců

  • 1Department of Steroids and Proteohormones, Institute of Endocrinology, Prague, Czech Republic. mhill@endo.cz.

Physiological Research
|October 23, 2020
PubMed
Summary

Aging brings physical decline and increased disease risk. However, interventions targeting the hypothalamic-pituitary-adrenal axis, alongside lifestyle changes, can mitigate these aging-related changes.

More Related Videos

An Ex vivo Model to Study Hormone Action in the Human Breast
12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

11.8K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.2K

Related Experiment Videos

Last Updated: Dec 4, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

2.3K
An Ex vivo Model to Study Hormone Action in the Human Breast
12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

11.8K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.2K

Area of Science:

  • Gerontology and molecular biology, focusing on aging processes and interventions.

Background:

  • Aging involves physiological deterioration and increased susceptibility to diseases.
  • Small molecules play a crucial role in both normal aging and age-related pathologies.
  • The hypothalamic-pituitary-adrenal axis is implicated in age-related functional decline.

Purpose of the Study:

  • To investigate the role of small molecules in aging processes.
  • To explore potential therapeutic strategies for age-related changes.
  • To understand the impact of the hypothalamic-pituitary-adrenal axis on aging.

Main Methods:

  • Review of existing literature on aging, small molecules, and the hypothalamic-pituitary-adrenal axis.
  • Analysis of previously published results and data from other research groups.
  • Focus on physiological and pathophysiological processes associated with aging.

Main Results:

  • Age-related deterioration is significantly influenced by the hypothalamic-pituitary-adrenal axis.
  • Small molecules are key players in aging-related physiological and pathophysiological changes.
  • Evidence suggests that interventions can modify the course of aging.

Conclusions:

  • The negative effects of aging can be slowed, halted, or even reversed.
  • Targeting the hypothalamic-pituitary-adrenal axis offers a promising therapeutic avenue.
  • Lifestyle adjustments are crucial for managing and mitigating age-related decline.