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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Endoscopic imaging in inflammatory bowel disease: current developments and emerging strategies
Jouke J H van der Laan1, Anne M van der Waaij1, Ruben Y Gabriëls1
1Department of Gastroenterology and Hepatology, University Medical Centre Groningen , Groningen, The Netherlands.
Advanced endoscopy and artificial intelligence improve inflammatory bowel disease (IBD) assessment. Molecular and label-free imaging offer new ways to visualize biomarkers, aiding in healing and dysplasia detection for better IBD patient outcomes.
Area of Science:
- Gastroenterology and Endoscopic Imaging
- Biomedical Engineering
- Molecular Diagnostics
Background:
- Enhanced and magnified endoscopy represent significant advancements in imaging ileocolonic pathology in inflammatory bowel disease (IBD).
- Artificial intelligence (AI) is increasingly integrated to enhance these advanced endoscopic techniques.
- Challenges in IBD management include therapy non-response and delayed/missed detection of neoplastic lesions during surveillance.
Purpose of the Study:
- To review the clinical applications of advanced endoscopic imaging modalities in IBD.
- To explore the potential of molecular imaging and label-free techniques to address current limitations in IBD assessment.
- To evaluate the role of AI in augmenting endoscopic capabilities for IBD.
Main Methods:
- A comprehensive literature search was performed in PubMed/MEDLINE up to May 2020.
- The search focused on preclinical and clinical applications of various endoscopic techniques in IBD.
- Key technologies reviewed include high-definition white light endoscopy, chromoendoscopy, AI, confocal laser endomicroscopy, endocytoscopy, molecular imaging, optical coherence tomography, and Raman spectroscopy.
Main Results:
- Enhanced and magnified endoscopy have improved the assessment of the ileocolonic mucosa in IBD.
- Molecular imaging provides functional data by visualizing biological parameters, complementing morphological assessment.
- Label-free modalities offer visualization beyond the mucosal surface without requiring tracers.
Conclusions:
- Molecular imaging integrated into endoscopy can provide real-time in vivo visualization of biomarkers, addressing clinical challenges in IBD.
- Label-free modalities hold promise for optimizing the endoscopic evaluation of mucosal healing and dysplasia detection in IBD patients.
- These advanced imaging techniques, including AI, are poised to improve IBD diagnosis and surveillance.
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