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A gadolinium-based magnetic ionic liquid for dispersive liquid-liquid microextraction.

Mohamed A Abdelaziz1,2, Fotouh R Mansour3,4, Neil D Danielson5

  • 1Department of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.

Analytical and Bioanalytical Chemistry
|October 23, 2020
PubMed
Summary

A novel magnetic ionic liquid (MIL) containing gadolinium offers enhanced extraction efficiency for sartan antihypertensive drugs. This magnetic liquid-liquid microextraction (DLLME) method improves sensitivity and reduces analysis time for pharmaceutical analysis.

Keywords:
Dispersive liquid–liquid microextractionHigh-performance liquid chromatographyMagnetic ionic liquidsSartans

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Dispersive liquid-liquid microextraction (DLLME) is a widely used sample preparation technique.
  • Magnetic ionic liquids (MILs) offer unique properties for extraction applications.

Purpose of the Study:

  • To investigate a novel hydrophobic gadolinium-based MIL as an extraction solvent for DLLME.
  • To evaluate the efficiency of this MIL for the microextraction of sartan antihypertensive drugs.

Main Methods:

  • Synthesis and characterization of a gadolinium-based MIL.
  • Application of the MIL in DLLME for sartan extraction.
  • Analysis of extracted sartans using reversed-phase HPLC with UV detection.

Main Results:

  • The gadolinium-MIL exhibited favorable properties including low water miscibility and high magnetic susceptibility.
  • The MIL demonstrated superior extraction efficiency compared to iron or manganese analogues.
  • Optimized DLLME procedures coupled with HPLC achieved low limits of quantitation (LOQs) and high enrichment factors for sartans.

Conclusions:

  • The gadolinium-based MIL is a promising extraction solvent for DLLME.
  • The developed method offers improved sensitivity, reproducibility, and reduced analysis time for sartan determination.
  • This approach holds potential for the analysis of pharmaceuticals in complex aqueous matrices.