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Local Immunodeficiency: Role of Neutral Viruses.

Leonid Bunimovich1, Longmei Shu2

  • 1School of Mathematics, Georgia Institute of Technology, Atlanta, GA, 30332-0160, USA.

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|October 23, 2020
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Neutral viruses can cause local immunodeficiency by supporting persistent viruses, but only at low concentrations and with marginal stability. Altruistic viruses are needed for stable local immunodeficiency.

Keywords:
Altruistic and persistent virusesCross-immunoreactivity networkLocal immunodeficiencyNeutral

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Area of Science:

  • Virology
  • Immunology
  • Theoretical Biology

Background:

  • Local immunodeficiency is a state where the immune system is weakened in a specific area.
  • Altruistic viruses are known to maintain stable local immunodeficiency.
  • The role of neutral viruses in this phenomenon has not been fully elucidated.

Purpose of the Study:

  • To analyze the role of neutral viruses in establishing local immunodeficiency.
  • To investigate the stability and viral concentration maintained by neutral viruses.
  • To identify minimal cross-immunoreactivity networks for stable local immunodeficiency.

Main Methods:

  • Theoretical analysis of viral interactions.
  • Modeling of cross-immunoreactivity networks.
  • Comparison of neutral versus altruistic viral roles.

Main Results:

  • Neutral viruses can induce local immunodeficiency by supporting persistent viruses.
  • This state is characterized by bounded (low) concentrations of persistent viruses.
  • Local immunodeficiency induced by neutral viruses is only marginally stable.
  • A minimal cross-immunoreactivity network for stable local immunodeficiency was presented.

Conclusions:

  • Neutral viruses can contribute to local immunodeficiency, albeit with limitations in stability and viral load.
  • Further research is needed to understand virus roles (persistent, altruistic, neutral) and network topology effects.
  • Synthetic biology can aim to construct minimal networks exhibiting stable local immunodeficiency.