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Association between serum paraoxonase 1 activity and its polymorphisms with multiple sclerosis: a systematic review
Nader Salari1,2, Shna Rasoulpoor3, Amin Hosseinian-Far4
1Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Summary
Paraoxonase 1 (PON1) activity and its genetic variations are linked to multiple sclerosis (MS) pathogenesis. Reduced PON1 function may contribute to MS, with specific PON1 polymorphisms increasing disease risk.
Area of Science:
- Neuroscience
- Biochemistry
- Genetics
Background:
- Human serum paraoxonase (PON) is a liver-synthesized enzyme transported by HDL.
- Paraoxonase 1 (PON1) is a key enzyme with antioxidant properties, protecting against lipid oxidation.
- PON1 activity in the brain suggests a role in neurological disorders.
Purpose of the Study:
- To investigate the role of PON1 and its polymorphisms in multiple sclerosis (MS).
- To explore potential therapeutic targets for MS by understanding PON1's involvement.
Main Methods:
- Systematic review of articles from multiple Persian and international databases.
- Keywords used: Paraoxonase 1, polymorphism, multiple sclerosis, PON1.
- Analysis of existing literature on PON1's association with MS.
Main Results:
- PON1 is a potential factor in MS pathogenesis, crucial for antioxidant protection.
- Oxidative stress and lipid peroxidation are implicated in MS development and negatively affect PON1.
- Reduced PON1 activity may be a factor in restoring MS pathogenesis.
Conclusions:
- Decreased PON1 activity and polymorphisms are linked to various neurological diseases.
- Specific PON1 alleles (PON1-55M in Italians, PON1-192Q in Poles) are associated with increased MS risk.
- PON1 polymorphisms do not appear to influence MS onset age or disease type.
