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Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
Published on: July 21, 2017
Brain lipoprotein lipase is responsive to nutritional and hormonal modulation
L A Gavin1, R R Cavalieri, M Moeller
1Division of Endocrinology-Metabolism, Veterans Administration Medical Center, San Francisco, CA 94121.
Metabolism: Clinical and Experimental
|October 1, 1987
Summary
This study reveals that fasting and diabetes reduce brain and adipose lipoprotein lipase (LPL) activity, while increasing heart LPL. Thyroid hormones also influence LPL activity in these tissues.
Area of Science:
- Biochemistry
- Endocrinology
- Neuroscience
Background:
- Lipoprotein lipase (LPL) activity, crucial for lipid metabolism, has been identified in the rat brain.
- Understanding the biological significance and regulatory factors of brain LPL is essential for comprehending brain lipid homeostasis.
Purpose of the Study:
- To further characterize the biological significance of brain lipoprotein lipase (heparin releasable component).
- To elucidate the regulatory factors influencing brain lipoprotein lipase activity.
Main Methods:
- Comparative analysis of heparin-releasable lipoprotein lipase activity in brain, adipose, and heart tissues of rats under fasted and diabetic conditions.
- Investigated the effects of refeeding, insulin replacement, and thyroid hormone (T3) therapy on LPL activity.
- Examined the impact of hypothyroidism and hyperthyroidism on tissue LPL activity.
Main Results:
- Fasting and diabetes significantly decreased brain and adipose LPL activity but increased heart LPL activity.
- Refeeding and insulin replacement reversed the effects of fasting and diabetes on LPL activity, respectively.
- Hypothyroidism decreased brain LPL activity while increasing adipose and heart LPL activity; T3 replacement reversed these effects, though hyperthyroidism tended to reduce brain LPL.
Conclusions:
- Brain, adipose, and heart lipoprotein lipase activities are differentially regulated by nutritional status and thyroid hormones.
- Insulin positively correlates with adipose LPL but not brain or heart LPL.
- Thyroid status significantly impacts brain LPL activity in a non-linear manner.
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