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Updated: Dec 4, 2025

A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device
Published on: January 26, 2010
Sliding mode control for a fractional-order non-linear glucose-insulin system
Muhammad Waleed Khan1, Muhammad Abid2, Abdul Qayyum Khan2
1PIEAS Artificial Intelligence Center (PAIC), Islamabad, Pakistan. eng.mwkhan@gmail.com.
Abstract:
By providing the generalisation of integration and differentiation, and incorporating the memory and hereditary effects, fractional-order modelling has gotten significant attention in the past few years. One of the extensively studied and utilised models to describe the glucose-insulin system of a human body is Bergman's minimal model. This non-linear model comprises of integer-order differential equations. However, comparison with the experimental data shows that the fractional-order version of Bergman's minimal model is a better representative of the glucose-insulin system than its original integer-order model. To design a control law for an artificial pancreas for a diabetic patient using a fractional-order model, different techniques, including feedback linearisation, have been applied in the literature. The authors' previous work shows that the fractional-order version of Bergman's model describes the glucose-insulin system in a better way than the integer-order model. This study applies the sliding mode control technique and then compares the obtained simulation results with the ones obtained using feedback linearisation.
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