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Related Experiment Video

Updated: Dec 4, 2025

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

Omics research in vascular calcification.

Meng Duan¹, Wen-Li Zhao², Le Zhou²

¹Research Lab of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541100, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|October 23, 2020

Summary

Vascular calcification, a mineral buildup in blood vessels, lacks effective treatments. Omics technologies offer new ways to understand and potentially treat this condition.

Keywords:

Epigenomics Genomics Omics Transcriptomics Vascular calcification Vascular smooth muscle cells

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Area of Science:

Biochemistry
Pathology
Genomics

Background:

Vascular calcification (VC) involves hydroxyapatite deposition in blood vessels, linked to aging, atherosclerosis, cardiovascular disease (CVD), and diabetes mellitus (DM).
VC mechanisms include cellular changes, extracellular vesicles, calcium-phosphate imbalance, and dysregulation of inducers/inhibitors.
Current treatments for VC are limited, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

To review the role of omics technologies in understanding vascular calcification mechanisms.
To explore the potential of omics approaches for identifying new biomarkers and therapeutic targets for VC.

Main Methods:

Systematic review of articles published over the last twenty years.
Focus on omics technologies: genomics, epigenomics, transcriptomics, proteomics, and metabolomics.

Main Results:

Omics technologies provide powerful tools for elucidating complex biochemical processes in VC.
These technologies can identify novel biomarkers for characterizing VC pathology.
Omics data can guide the development of targeted therapeutic interventions for VC.

Conclusions:

Omics technologies hold significant promise for advancing our understanding of vascular calcification.
Future research utilizing omics approaches may lead to effective preventive and therapeutic strategies for VC.