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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
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Omics research in vascular calcification.

Meng Duan1, Wen-Li Zhao2, Le Zhou2

  • 1Research Lab of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541100, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 23, 2020
PubMed
Summary

Vascular calcification (VC) involves mineral buildup in blood vessels, linked to aging and diseases. Omics technologies offer new insights for understanding and treating this condition.

Keywords:
EpigenomicsGenomicsOmicsTranscriptomicsVascular calcificationVascular smooth muscle cells

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Area of Science:

  • Biomedical research
  • Cardiovascular science
  • Pathology

Background:

  • Vascular calcification (VC) is a pathological process involving hydroxyapatite deposition in the vascular system.
  • VC is associated with aging, atherosclerosis, cardiovascular disease (CVD), and diabetes mellitus (DM).
  • Current treatments for VC are limited, necessitating novel research approaches.

Purpose of the Study:

  • To review the application of omics technologies in vascular calcification research.
  • To highlight the current state, challenges, and future directions of omics in VC.
  • To identify potential therapeutic targets for VC-related diseases.

Main Methods:

  • Comprehensive literature review of articles published in the last twenty years.
  • Focus on omics technologies including genomics, epigenomics, transcriptomics, proteomics, and metabolomics.
  • Analysis of omics data for understanding VC pathophysiology.

Main Results:

  • Omics technologies provide a novel approach to elucidate the complex mechanisms of VC.
  • Review identifies key challenges and limitations in current omics-based VC research.
  • Potential therapeutic targets for VC have been highlighted through omics studies.

Conclusions:

  • Omics technologies are crucial for advancing the understanding of vascular calcification.
  • Further research utilizing omics is needed to develop effective preventive and targeted treatments for VC.
  • Translating omics findings into clinical practice holds promise for managing VC-related diseases.