[Regulation of expression of the htpR gene in Escherichia coli]

The hybrid operon htpR: ATP was obtained, in which the expression of the aminoglycoside phosphotransferase gene is controlled by the promoter of the htpR gene of Escherichia coli. It was shown that the transcription of the htpR gene is not induced during the "heat shock". The basal level of the htpR gene transcription in htpR mutants was found to be two times higher than that in the strains of the "wild type". These findings suggested that the expression of the htpR gene is autoregulated. Hybridization experiments demonstrated that the genome of Pseudomonas bacteria contains the htpR-like gene.