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Updated: Dec 4, 2025

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence
Edward Po-Fan Chu1, Chia-Hung Lin2, Candy Hsin-Hua Cho1
1Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Abstract:
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D pathogenesis. In particular, families with complete disease penetrance offer an opportunity to further dissect T1D risk loci. Here, we describe the generation of three hiPSC lines from a T1D family with sequence variants associated with autoimmunity.
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