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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases

Cheng-Wei Chou1,2, Yu-Kai Huang1, Ting-Ting Kuo3

  • 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan.

International Journal of Molecular Sciences
|October 24, 2020
PubMed

Insights

A disintegrin and a metalloprotease 9 (ADAM9) is crucial in cancer. Understanding its role in tumor progression and metastasis is key to developing new anti-cancer therapies.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • ADAM9 is a membrane-anchored protein with disintegrin and metalloprotease domains.
  • It regulates cell adhesion and ectodomain shedding of cell surface proteins.
  • ADAM9 impacts development, inflammation, and degenerative diseases.

Purpose of the Study:

  • To review the biological functions of ADAM9.
  • To summarize ADAM9's role in pathophysiological diseases and cancer.
  • To present advances in ADAM9-targeted anti-cancer strategies.

Main Methods:

  • Literature review of ADAM9's biological functions.
  • Analysis of ADAM9's involvement in various cancers.
  • Summary of current therapeutic strategies targeting ADAM9 pathways.

Main Results:

  • ADAM9 overexpression correlates with tumor aggressiveness and poor prognosis in several cancers.
  • ADAM9 promotes tumor progression, therapeutic resistance, and metastasis via proteolytic and non-proteolytic pathways.
  • ADAM9 is implicated in diverse physiological and pathological processes.

Conclusions:

  • Comprehensive understanding of ADAM9 mechanisms is vital for anti-cancer drug development.
  • ADAM9 represents a promising therapeutic target for various cancers.
  • Further research into ADAM9 pathways could lead to novel cancer treatments.
Keywords:
ADAM9biological functioncancerinflammation

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