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The Tumor Microenvironment of Pancreatic Cancer

Eva Karamitopoulou1

  • 1Pancreatic Cancer Research Group, Institute of Pathology University of Bern, CH-3008 Bern, Switzerland.

Cancers
|October 24, 2020
PubMed

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The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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