Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elezanumab for the treatment of spinal cord injury: assessing the clinical development journey to date.

Expert opinion on investigational drugs·2026
Same author

The Risk Assessment Case for Public Health Regulation Worldwide of the Concussion Crisis in Sports.

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·2026
Same author

FLOW Trial - The effect of fluoxetine combined with exercise on motor recovery after stroke: an RCT.

Archives of physical medicine and rehabilitation·2026
Same author

The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Assessment of Angiopep-2 targeting intracerebral α-synuclein aggregates in a PFF-induced rat model of Parkinson's disease based on 7T CEST-MRI.

Brain research bulletin·2026
Same author

Variations in Managing Acute Spinal Cord Injury in the North American Clinical Trials Network and Partner Institutes.

Global spine journal·2026

Related Experiment Video

Updated: Dec 4, 2025

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.5K

A Promising Subject-Level Classification Model for Acute Concussion Based on Cerebrovascular Reactivity Metrics.

Reema Shafi1, Julien Poublanc1, Lashmi Venkatraghavan2

  • 1Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

Journal of Neurotrauma
|October 24, 2020
PubMed
Summary

Concussed individuals show altered cerebrovascular reactivity (CVR) with faster and larger blood flow responses compared to healthy controls. These vascular changes may offer sensitive markers for concussion assessment.

Keywords:
blood oxygen level dependent imagingcerebral blood flowcerebrovascular reactivityconcussionsex differences

More Related Videos

Objectively Assessing Sports Concussion Utilizing Visual Evoked Potentials
12:11

Objectively Assessing Sports Concussion Utilizing Visual Evoked Potentials

Published on: April 27, 2021

3.7K
A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
11:32

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Published on: December 8, 2014

13.1K

Related Experiment Videos

Last Updated: Dec 4, 2025

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.5K
Objectively Assessing Sports Concussion Utilizing Visual Evoked Potentials
12:11

Objectively Assessing Sports Concussion Utilizing Visual Evoked Potentials

Published on: April 27, 2021

3.7K
A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
11:32

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Published on: December 8, 2014

13.1K

Area of Science:

  • Neuroimaging
  • Vascular Physiology
  • Traumatic Brain Injury

Background:

  • Concussion research often overlooks vascular dysfunction, focusing instead on neuronal damage.
  • Cerebrovascular reactivity (CVR) metrics may be more sensitive indicators of concussion than neuronal integrity measures.
  • Blood flow dysregulation is a known consequence of traumatic brain injury.

Purpose of the Study:

  • To assess changes in CVR metrics during the acute phase of concussion.
  • To evaluate the potential of CVR metrics for individual subject assessment post-concussion.
  • To investigate sex-specific differences in CVR responses.

Main Methods:

  • A case-control study involving 20 concussed participants and 20 healthy controls.
  • Cerebrovascular reactivity (CVR) assessment using blood oxygen-level dependent (BOLD) MRI.
  • Standardized vasodilatory stimulus with controlled end-tidal partial pressure of CO2 (PETCO2).
  • Analysis of CVR metrics (speed and magnitude) in whole brain, gray matter (GM), and white matter (WM).
  • Sex-stratified analysis and receiver operating characteristic (ROC) analysis for classification.

Main Results:

  • Concussed participants exhibited greater CVR magnitude and faster response speeds compared to healthy controls.
  • White matter (WM) demonstrated higher classification accuracy than gray matter (GM).
  • WM-CVR metrics achieved an area under the curve of 0.94 (males) and 0.90 (females) for speed and magnitude, respectively.
  • Sex-stratified ROC analysis showed high diagnostic potential for WM-CVR metrics.

Conclusions:

  • Altered cerebrovascular reactivity (CVR) is present in the acute phase of concussion.
  • WM-CVR metrics show promise for differentiating concussed individuals from healthy controls.
  • Further research is warranted to compare CVR metrics with structural injury metrics for concussion diagnosis and prognosis.