Functional connectivity and quality of life in young adults with cerebral palsy: a feasibility study
Diana Tajik-Parvinchi1,2,3, Andrew Davis4, Sophia Roth4
1Department of Pediatrics and CanChild, McMaster University, Hamilton, Ontario, L8S 1C7, Canada. dparvinchi@mcmaster.ca.
Insights
Resting-state functional connectivity (FC) is feasible in young adults with Cerebral Palsy (CP) without sedation. Higher well-being in CP is linked to brain connectivity in regions supporting emotion regulation.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Clinical Neuroscience
Background:
- Cerebral Palsy (CP) affects movement and posture due to immature brain injury.
- Research on CP brain changes often overlooks late adolescence and early adulthood.
- Understanding functional brain changes during this transition is crucial for adult CP care.
Purpose of the Study:
- To assess the feasibility of obtaining high-quality resting-state functional connectivity (FC) data in young adults with CP without sedation.
- To explore the relationship between FC patterns and mood, pain, fatigue, and quality of life in young adults with CP.
Main Methods:
- Collected resting-state functional MRI data from 9 young adults (18-29 years) with CP.
- Employed rigorous head motion correction and quality control protocols post-preprocessing.
- Utilized standard seed regions for identifying functional connectivity networks.
Main Results:
- High-quality resting-state FC data were successfully acquired from young adults with CP without sedation.
- Identified specific functional connectivity networks within the dataset.
- Found an association between higher well-being scores and increased FC between the Medial Pre-Frontal Cortex and right Lateral Parietal regions, linked to prosocial and emotion regulation skills.
Conclusions:
- Resting-state FC assessments are feasible in young adults with CP across varying motor abilities, without requiring sedation.
- Identified a neural circuitry associated with self-reported quality of life and emotion regulation in this population.
- These findings suggest potential targets for future research on mental health and well-being interventions in CP.
Background:
Cerebral Palsy (CP) is a group of disorders that affect the development of movement and posture. CP results from injuries to the immature brain during the prenatal, perinatal, or postnatal stage of development. Neuroimaging research in CP has focused on the structural changes of the brain during early development, but little is known about brain's structural and functional changes during late adolescence and early adulthood, a period in time when individuals experience major changes as they transition into adulthood. The work reported here served as a feasibility study within a larger program of research (MyStory Study). We aimed to determine whether it would be feasible to scan and obtain good quality data without the use of sedation during a resting state condition for functional connectivity (FC) analyses in young adults with CP. Second, we aimed to identify the FC pattern(s) that are associated with depressive mood ratings, indices of pain and fatigue, and quality of life in this group.
Methods:
Resting state functional images were collected from 9 young people with CP (18-29 years). We applied a stringent head motion correction and quality control methods following preprocessing.
Results:
We were able to scan and obtain good quality data without the use of sedation from this group of young individuals with CP who demonstrated a range of gross motor ability. The functional connectivity networks of interest were identified in the data using standard seed regions. Our analyses further revealed that higher well-being scores were associated with higher levels of FC between the Medial Pre-Frontal Cortex and the right Lateral Parietal regions, which are implicated in prosocial and emotion regulations skills. The implications of this association are discussed.
Conclusion:
The findings of the present study demonstrate that it is feasible to conduct resting state functional connectivity in young adults with CP with different gross motor abilities without the use of sedation. Our results also highlight a neural circuitry that is associated with the self-report of quality of life and emotion regulation. These findings identify these regions/circuitries as important seeds for further investigations into mental health and wellbeing in CP.
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