Association between daily egg intake and lipid profiles in adults from the Henan rural cohort study

The association between daily egg intake and dyslipidemia remains a contentious issue. Therefore, our study was aimed to explore the relation of daily egg intake to lipid profile; and whether the association was mediated by body mass index (BMI).

A total of 39,021 participants (18-79 years) were enrolled from the Henan Rural Cohort Study. Data on egg consumptions and blood lipid indices were collected with standardized processes. Logistic regression and restricted cubic splines were used to estimate the odds ratio (OR) and 95% confidence intervals (95% CI). Mediation analysis using bootstrap was performed to examine the contribution of BMI to daily egg intake and HDL-C. The participants were divided into 3 egg intake groups (＜26.79 g/d, 26.79-62.50 g/d, ＞62.5 g/d). According to our results, comparing with the low daily egg consumption group, medium and high egg intake tertiles were related with increased high-TC (OR_medium = 1.546, 95%CI (1.417,1.688); OR_high = 1.902,95%CI (1.703, 2.124)), high LDL-C (OR_medium = 1.224, 95%CI (1.121, 1.337); OR_high = 1.368,95%CI (1.220, 1.534)) and non-HDL-C(OR_medium = 1.486,95%CI(1.358,1.625); OR_high = 1.715,95%CI (1.499, 1.888)), as well as inversely associated with high-TG (OR_medium = 0.825, 95% CI(0.778, 0.875); OR_high = 0.778,95%CI(0.718,0.844)) and low HDL-C (OR_medium = 0.914, 95%CI (0.858, 0.973); OR_high = 0.756,95%CI(0.693,0.825)). Moreover, mediation analysis showed that both of BMI and WC partly mediated the relationship between daily egg intake and HDL-C.

Our results suggested that the daily egg intake may have a role in effect on lipid profiles, and the effect of daily egg intake on HDL-C may be partly mediated by BMI and WC.