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Long-range phase synchronization of high-frequency oscillations in human cortex.
G Arnulfo1,2, S H Wang3,4,5, V Myrov3,5
1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland. gabriele.arnulfo@dibris.unige.it.
Nature Communications
|October 24, 2020
Summary
High-frequency oscillations (HFOs) synchronize across distant brain regions, challenging previous assumptions. This widespread HFO synchronization reveals novel insights into neuronal communication and brain network dynamics.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Neuronal oscillations below 100 Hz synchronize across brain areas, regulating circuit communication.
- Faster oscillations (>100 Hz) were traditionally viewed as local phenomena, lacking large-scale synchronization.
Purpose of the Study:
- To investigate whether high-frequency oscillations (HFOs) synchronize between widely distributed brain regions.
- To characterize the properties and functional significance of HFO synchronization.
Main Methods:
- Analysis of human intracerebral recordings.
- Examination of HFO synchronization patterns, frequency peaks, connectivity, and laminar profiles.
- Investigation of HFO synchronization during a response-inhibition task.
Main Results:
- Demonstrated synchronization of 100-400 Hz HFOs across distributed brain regions.
- Identified stable community structuring within HFO synchronization patterns.
- Observed a laminar profile for HFO synchronization distinct from lower frequencies.
- Showed transient enhancement and suppression of HFO synchronization in specific frequency bands during task performance.
Conclusions:
- HFO synchronization represents a significant form of neuronal spike-timing relationships.
- HFO synchronization serves as a mesoscopic indicator of neuronal communication.
- Challenges the notion that fast neuronal activities are exclusively local phenomena.
