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Exparel for Postoperative Pain Management: a Comprehensive Review
Alan David Kaye1, Cassandra Armstead-Williams2, Farees Hyatali3
1Department Pharmacology, Toxicology, and Neuroscience, LSU Health Shreveport, Shreveport, LA, USA.
Current Pain and Headache Reports
|October 24, 2020
Summary
Multimodal pain management, including long-acting local anesthetics like Exparel, offers effective postsurgical pain control. Limiting opioid use is crucial to combat the opioid epidemic and improve patient safety.
Area of Science:
- Anesthesiology
- Pain Management
- Pharmacology
Background:
- Multimodal pain management is the standard for postsurgical pain.
- Opioid use for acute pain management contributes to the opioid epidemic.
- Opioid-related adverse effects are a leading cause of preventable hospital harm.
Purpose of the Study:
- To review the effectiveness of multimodal analgesia in postsurgical pain.
- To highlight the benefits of limiting opioid use in the postsurgical setting.
- To evaluate the role of long-acting local anesthetics in pain management.
Main Methods:
- Literature review on multimodal pain management strategies.
- Analysis of studies on opioid-sparing techniques.
- Evaluation of evidence for long-acting liposomal bupivacaine (Exparel).
Main Results:
- An opioid-centric approach is not necessary for optimal postsurgical outcomes.
- Alternative regimens, including multimodal analgesia, are now standard practice.
- Exparel demonstrates efficacy and a long duration of action for postoperative pain control.
Conclusions:
- Multimodal analgesia is essential for effective postsurgical pain management.
- Limiting opioid use reduces adverse events and healthcare costs.
- Exparel is a significant component of multimodal postoperative pain control.
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