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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Related Experiment Video

Updated: Dec 4, 2025

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
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Induced pluripotent stem cells from farm animals.

Yue Su1, Jiaqi Zhu1, Saleh Salman1

  • 1Department of Animal Science, Institute for Systems Genomics, University of Connecticut, Storrs, CT.

Journal of Animal Science
|October 24, 2020
PubMed
Summary

Induced pluripotent stem cells (iPSCs) from farm animals offer significant value, but challenges like factor silencing and limited development persist. Future research aims to overcome these hurdles for complete somatic cell reprogramming.

Keywords:
aviandifferentiationinduced pluripotent stem cellslivestockpluripotencyreprogramming

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Area of Science:

  • Stem cell biology
  • Reproductive biology
  • Agricultural science

Background:

  • Induced pluripotent stem cells (iPSCs) technology has advanced stem cell research across species.
  • Domesticated animal iPSCs are valuable for research, agriculture, and therapeutics.
  • Despite progress, challenges hinder the generation of bona fide farm animal iPSCs.

Purpose of the Study:

  • To review the progress in generating iPSCs from domestic farm animals.
  • To highlight the obstacles in farm animal iPSC generation.
  • To discuss future directions for complete somatic cell reprogramming.

Main Methods:

  • Review of existing literature on iPSC generation in domestic animals.
  • Focus on swine, ruminants, horses, and avian species.
  • Analysis of challenges and potential solutions.

Main Results:

  • Significant advancements in generating iPSCs from various farm animals.
  • Persistent issues include silencing exogenous factors, reliance on external factors, and restricted in vivo development.
  • Species-specific differences in iPSC generation efficiency and characteristics.

Conclusions:

  • Farm animal iPSCs hold immense scientific, economic, and societal potential.
  • Overcoming reprogramming barriers is crucial for realizing their full therapeutic and agricultural applications.
  • Further research is needed to achieve complete reprogramming and establish reliable iPSC lines.