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Superagonistic CD28 stimulation induces IFN-γ release from mouse T helper 1 cells in vitro and in vivo

Stephanie Haack1, Sarah Baiker1, Jan Schlegel2

  • 1Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

European Journal of Immunology
|October 24, 2020
PubMed

Like human Th1 cells, mouse Th1 cells also secrete IFN-γ upon stimulation with a superagonistic anti-CD28 monoclonal antibody (CD28-SA). Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions greatly increased IFN-γ release. Our data stress the utility of the mouse as a model organism for immune responses in humans.

Keywords:
CD28Superagonistic antibodyTh1 cellscytokine releaseinterferon γ

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