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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Updated: Dec 4, 2025

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Histopathologic Correlates of Kidney Function: Insights From Nephrectomy Specimens.

Ping Li1, Shruti Gupta2, Suraj S Mothi2

  • 1Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Nephrology, State Key Laboratory of Kidney Disease, National Clinical Research Center for Kidney Disease, Chinese PLA General Hospital, Beijing, China.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|October 25, 2020
PubMed
Summary

Kidney disease severity, including glomerulosclerosis and interstitial fibrosis, correlates with reduced kidney function (eGFR). While older individuals show more severe changes, age does not alter this association between kidney pathology and eGFR.

Keywords:
Nephrectomyagearteriosclerosisestimated glomerular filtration rate (eGFR)glomerulosclerosishistopathologic lesioninterstitial fibrosisrenal functionrenal histopathology

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Area of Science:

  • Nephrology
  • Pathology
  • Geriatric Medicine

Background:

  • Existing kidney function and pathology data often lack elderly representation.
  • Understanding kidney histopathology in diverse age groups is crucial for generalizability.

Purpose of the Study:

  • To examine the association between kidney histopathologic changes and estimated glomerular filtration rate (eGFR).
  • To determine if age modifies the relationship between kidney pathology and eGFR.

Main Methods:

  • Retrospective cross-sectional study of 1,347 patients undergoing nephrectomy.
  • Analysis of non-neoplastic kidney tissue for glomerulosclerosis (GS), interstitial fibrosis/tubular atrophy (IFTA), and arteriosclerosis (AS).
  • Correlation of histopathologic findings with eGFR, stratified by age.

Main Results:

  • Greater degrees of GS, IFTA, and AS were significantly associated with lower eGFR.
  • Older individuals exhibited a higher prevalence of severe GS and IFTA.
  • The association between kidney histopathology and eGFR was consistent across all age groups.

Conclusions:

  • Kidney histopathology findings correlate with estimated glomerular filtration rate.
  • While advanced kidney changes are more common in older adults, this does not change the fundamental relationship with kidney function.