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The role of non-coding RNA on macrophage modification in tuberculosis infection

Zhaohui Wang1, Hui Xu2, Zhenhong Wei2

  • 1College of Clinical Medicine, Gansu Chinese Medical University, Lanzhou, PR China.

Microbial Pathogenesis
|October 25, 2020
PubMed

Insights

Tuberculosis (TB) persists by evading immune responses within macrophages. Noncoding RNAs regulate these macrophages, offering potential therapeutic targets and diagnostic biomarkers for TB disease.

Area of Science:

  • Immunology
  • Molecular Biology
  • Infectious Diseases

Background:

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a leading infectious killer globally.
  • Mtb evades host immune responses, with macrophages being key sites for its growth and persistence.
  • Altered macrophage functions are critical in determining TB outcomes like latency or dissemination.

Purpose of the Study:

  • To review the regulatory roles of noncoding RNAs in macrophage responses during TB infection.
  • To explore how noncoding RNAs influence macrophage functions in the context of Mtb.

Main Methods:

  • Literature review focusing on noncoding RNAs and macrophage biology in TB.
  • Analysis of regulatory mechanisms at the posttranscriptional level.

Main Results:

  • Noncoding RNAs are identified as crucial posttranscriptional regulators of macrophage functions relevant to TB.
  • These noncoding RNAs impact macrophage discrimination and host defense against Mtb.

Conclusions:

  • Understanding noncoding RNA-macrophage interactions in TB is vital.
  • This knowledge can guide the development of novel therapeutic strategies and diagnostic biomarkers for TB.
Keywords:
Circular RNALong non-coding RNAMacrophagesMicroRNATuberculosis

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