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A Potential Role for IL-4 and IL-13 in an Alopecia Areata-Like Phenotype: A Clinical Perspective
Dustin H Marks1, Maryanne M Senna2
1Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.
The Journal of Investigative Dermatology. Symposium Proceedings
|October 25, 2020
Abstract:
Although alopecia areata (AA) has been traditionally classified as a strictly T helper type 1-mediated process, the T helper type 2 (Th2) pathway may contribute to an AA-like phenotype in some individuals. Herein, we describe three clinical cases that support the potential role of Th2 activity through the upregulation of IL-4 and IL-13 in an AA-like phenotype.

