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Stem Cell Mobilization and Autologous Transplant for Immunoglobulin Light-Chain Amyloidosis

Morie A Gertz1, Stefan Schonland2

  • 1Division of Hematology, Mayo Clinic, 200 Southwest First Street, W10, Rochester, MN 55905, USA.

Hematology/Oncology Clinics of North America
|October 25, 2020
PubMed

Stem cell transplantation was one of the first proven effective regimens for the management of immunoglobulin light-chain amyloidosis. Criteria for patient selection and the mobilization regimen become important features in ensuring a safe outcome. The technique of stem cell transplantation has evolved considerably in parallel with the development of new chemotherapeutic agents for the management of amyloidosis. Optimal outcomes require both the use of effective novel agent induction and appropriate application of high-dose chemotherapy with subsequent stem cell reconstitution.

Keywords:
High-dose chemotherapyMelphalanMobilizationTransplantation

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