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Migraine neuroscience: from experimental models to target therapy
Rosaria Greco1, Chiara Demartini2, Roberto De Icco2,3
1Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy. rosaria.greco@mondino.it.
Summary
Recent advances in migraine research, utilizing experimental models, have identified key brain pathways and molecules. This has led to new targeted therapies, including monoclonal antibodies for migraine prevention.
Area of Science:
- Neurology
- Neuroscience
- Pharmacology
Background:
- Migraine pathogenesis involves complex brain networks and neurotransmission pathways.
- Recent scientific efforts have significantly advanced understanding of migraine mechanisms.
Purpose of the Study:
- To review recent advances in migraine science.
- To highlight the role of experimental models in understanding migraine.
- To discuss novel therapeutic approaches for migraine prevention.
Main Methods:
- Utilized pre-clinical and clinical experimental models.
- Reviewed findings on brain structures and molecules involved in migraine.
- Examined the development of targeted therapies.
Main Results:
- Experimental models provided insights into brain structures mediating migraine attacks.
- Elucidated the role of neurotransmission pathways and key molecules.
- Validated novel monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor.
Conclusions:
- Novel therapies, such as CGRP-targeted monoclonal antibodies, are now available for migraine prevention.
- These therapies have been validated in clinical trials and show promise for improving patient lives.
- Further therapeutic options are under development.
