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SIGLEC1 (CD169) as a potential diagnostical screening marker for monogenic interferonopathies

Banu Orak1,2, Gonza Ngoumou1,2, Frédéric Ebstein3

  • 1Pediatric Pneumology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|October 25, 2020
PubMed
Summary

No abstract available in PubMed .

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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