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Correlations between lipoprotein(a) gene polymorphisms and calcific aortic valve disease and coronary heart disease

Hongzhi Dong1,2, Hongliang Cong2, Jing Wang3

  • 1Graduate School, Tianjin Medical University, Tianjin, China.

The Journal of International Medical Research
|October 26, 2020
PubMed

Insights

Specific LPA gene polymorphisms are linked to elevated lipoprotein(a) levels, increasing the risk of calcific aortic valve disease (CAVD) and coronary heart disease (CHD) in Han Chinese individuals.

Area of Science:

  • Genetics and Cardiovascular Disease
  • Molecular Biology
  • Epidemiology

Background:

  • Lipoprotein(a) [Lp(a)] is a recognized risk factor for cardiovascular diseases.
  • The role of specific lipoprotein(a) gene (LPA) polymorphisms in calcific aortic valve disease (CAVD) and coronary heart disease (CHD) requires further investigation, particularly in diverse ethnic populations.

Purpose of the Study:

  • To examine the association between LPA gene polymorphisms and the risk of CAVD and CHD in the Han Chinese population.
  • To determine if specific LPA polymorphisms correlate with Lp(a) plasma levels in patients with CAVD and CHD.

Main Methods:

  • Case-control study involving 148 patients (71 with CAVD, 77 with CHD) and 71 controls.
  • Analysis of LPA polymorphisms (rs10455872, rs6415084, rs3798221, rs7770628) using SNaPshot SNP.
  • Measurement of Lp(a) and other lipid biomarkers.

Main Results:

  • Lp(a) levels were significantly higher in both CAVD and CHD groups compared to controls.
  • Polymorphisms rs3798221, rs6415084, and rs7770628 were associated with increased Lp(a) concentrations.
  • No significant differences in allelic frequencies for rs3798221, rs7770628, or rs6415084 were observed between the groups.

Conclusions:

  • Specific LPA gene polymorphisms (rs3798221, rs6415084, rs7770628) are associated with elevated Lp(a) levels.
  • Higher Lp(a) plasma levels, influenced by these polymorphisms, correlate with increased risk for CAVD and CHD.
Abstract

Keywords:
Han ChineseLipoprotein(a) gene polymorphismbiomarkercalcific aortic valve diseasecoronary heart diseasegenotype

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