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Stem Cell Niche01:26

Stem Cell Niche

5.9K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.9K
Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.9K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.0K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.0K
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

5.8K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.1K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.4K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Dec 4, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

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Research interdisciplinarity: STEM versus non-STEM.

Shahadat Uddin1, Tasadduq Imam2, Mohammad Mozumdar3

  • 1School of Project Management, Faculty of Engineering, The University of Sydney, Level 2, 21 Ross Street, Forest Lodge, NSW 2037 Australia.

Scientometrics
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

This study reveals dominant disciplines in interdisciplinary research. STEM research is led by Engineering, Biological Sciences, and Technology, while non-STEM research is led by Social Sciences and Humanities.

Keywords:
Interdisciplinary researchSTEM and non-STEM

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Isolation and Transplantation of Hematopoietic Stem Cells HSCs
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Area of Science:

  • Social Sciences
  • Humanities
  • STEM

Background:

  • Interdisciplinary research is increasing, but dominant disciplinary roles remain unclear.
  • It is unknown if discipline dominance differs between STEM and non-STEM research.

Purpose of the Study:

  • To investigate the contribution of individual disciplines in interdisciplinary research.
  • To identify dominant disciplines in STEM, non-STEM, and cross-disciplinary projects.

Main Methods:

  • Network analytics applied to metadata from Australian Research Council Discovery Grant Projects.
  • Analysis of successfully funded interdisciplinary research projects.

Main Results:

  • STEM-focused interdisciplinary research is led by Engineering, Biological Sciences, and Technology.
  • Non-STEM interdisciplinary research is dominated by Studies in Human Societies, Language, Communication and Culture, and History and Archaeology.
  • Cross-disciplinary projects involve Medical and Health Sciences (STEM) and Psychology/Cognitive Science and Studies in Human Societies (non-STEM).

Conclusions:

  • Interdisciplinarity is implemented heterogeneously across STEM and non-STEM fields.
  • Gaps exist in interdisciplinary collaborations among certain disciplines.