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Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a
A Bertolet1,2, V Grilj3, C Guardiola4
1Department of Radiation Oncology, Hospital of The University of Pennsylvania, Philadelphia, PA, USA.
Radiation Physics and Chemistry (Oxford, England : 1993)
|October 26, 2020
Summary
This study validates Geant4-DNA simulations against silicon microdosimeter measurements for low energy proton beams. The findings show excellent agreement, supporting the use of analytical methods for experimental verification of clinical microdosimetry.
Area of Science:
- Medical physics
- Radiation dosimetry
- Computational biology
Background:
- Microdosimetry is crucial for understanding radiation effects.
- Accurate simulations are needed for proton therapy.
- Silicon microdosimeters offer a potential alternative to traditional methods.
Purpose of the Study:
- To assess the agreement between silicon microdosimeter measurements and Geant4-DNA simulations.
- To validate an analytical microdosimetric model for low energy proton beams.
- To compare experimental and simulated lineal energy distributions.
Main Methods:
- Proton beams (2.0-4.5 MeV) were measured using a silicon microdosimeter and a tissue equivalent proportional counter (TEPC).
- SRIM simulations determined proton energy in silicon.
- Geant4-DNA simulated water cylinder sites, and an analytical model was applied.
Main Results:
- Tissue-equivalent distributions from silicon microdosimeters showed <1.2% deviation from Geant4-DNA simulations.
- The analytical method yielded <3.4% deviation from experimental results.
- High agreement was observed between simulated and measured proton microdosimetric distributions.
Conclusions:
- Geant4-DNA simulations in water closely match silicon microdosimeter measurements.
- The study supports the experimental verification of clinical microdosimetry using analytical methods.
- This work advances the accuracy of proton beam dosimetry.
