Related Experiment Video

Updated: Dec 4, 2025

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.2K

Rhabdomyoma association with atrioventricular septal defect in an infant: a rare coincidence

Ilker Mercan1, Muhammet Akyüz1, Onur Isık1

  • 1Department of Pediatric Heart Surgery, Izmir University Of Health Sciences Tepecik Training And Research Hospital, Sanayi Caddesi No:7 Bornova, İzmir, Turkey.

Indian Journal of Thoracic and Cardiovascular Surgery
|October 26, 2020
PubMed

Insights

Cardiac rhabdomyoma, a common childhood heart tumor often linked to tuberous sclerosis complex, typically regresses spontaneously. This case study highlights successful treatment of an asymptomatic rhabdomyoma with everolimus, avoiding surgical intervention.

Area of Science:

  • Pediatric Cardiology
  • Oncology
  • Genetics

Background:

  • Cardiac rhabdomyoma is the most frequent primary cardiac tumor in children.
  • It is frequently associated with tuberous sclerosis complex (TSC).
  • Spontaneous regression is common, but surgical intervention is necessary for obstructive symptoms.

Observation:

  • This study presents a case of an infant with atrioventricular septal defect and patent ductus arteriosus.
  • The infant also had an accompanying asymptomatic cardiac rhabdomyoma.
  • The tumor did not cause significant obstruction or symptoms.

Findings:

  • The asymptomatic cardiac rhabdomyoma was treated with everolimus.
  • This approach was chosen in line with current literature, avoiding surgical excision.
  • The treatment aimed to manage the rhabdomyoma without invasive procedures.

Implications:

  • This case suggests everolimus as a viable non-surgical option for asymptomatic cardiac rhabdomyomas.
  • It underscores the importance of considering medical management alongside surgical correction of congenital heart defects.
  • Further research is needed to clarify the relationship between rhabdomyomas and other congenital heart malformations.

Keywords:
Atrioventricular septal defectInfantRhabdomyoma

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

4.1K
Murine Fetal Echocardiography08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

17.9K

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
194
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
1.7K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
204
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
196
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
117
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
253