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Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior.

Yuta Yoshino1, Yogesh Dwivedi1

  • 1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.

Frontiers in Psychiatry
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are implicated in psychiatric disorders. This review examines their expression changes in postmortem human brains, focusing on suicidal behavior.

Keywords:
bipolar disorderlong non-coding RNAsmajor depressive disordermicroRNAsschizophrenia

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • The human genome contains a vast number of non-coding RNAs (ncRNAs) that do not produce proteins.
  • ncRNAs are classified into long non-coding RNAs (lncRNAs) and small RNAs, with small RNAs encompassing miRNAs, siRNAs, piRNAs, snoRNAs, and snRNAs.
  • ncRNAs, particularly lncRNAs and miRNAs, play crucial roles in brain function and are linked to psychiatric disorders.

Purpose of the Study:

  • To comprehensively review expression changes and functions of lncRNAs and miRNAs in psychiatric disorders.
  • To investigate the role of ncRNAs in suicidal behavior.
  • To summarize findings from postmortem human brain studies and briefly touch upon other small RNAs.

Main Methods:

  • Literature review focusing on lncRNA and miRNA expression in psychiatric disorders.
  • Analysis of studies utilizing postmortem human brain tissue.
  • Inclusion of data on other small RNAs like piwiRNAs, siRNAs, snRNAs, and snoRNAs.

Main Results:

  • ncRNAs, especially lncRNAs and miRNAs, show altered expression patterns in psychiatric disorders.
  • These alterations are observed in postmortem human brain samples.
  • Emerging evidence suggests a role for ncRNAs in suicidal behavior.

Conclusions:

  • Dysregulation of lncRNAs and miRNAs is associated with psychiatric conditions.
  • Further research into ncRNAs, including small RNAs, is crucial for understanding psychiatric disorders and suicidal behavior.
  • Postmortem brain studies provide valuable insights into the molecular mechanisms underlying these conditions.