Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testes: Histology01:27

Testes: Histology

2.2K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
2.2K
T Cell Types and Functions01:24

T Cell Types and Functions

1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

4.3K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
4.3K
Spermatogenesis01:41

Spermatogenesis

113.8K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
113.8K
Spermatogenesis01:22

Spermatogenesis

8.2K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.2K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

2.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Notice to: Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Epididymitis promotes formation of tertiary lymphoid organs in the cauda epididymidis.

Mucosal immunology·2025
Same author

Active vitamin D3 reduces testicular tissue damage and inflammation in mice with autoimmune orchitis.

Reproduction (Cambridge, England)·2025
Same author

Hidden diversity: Identification and characterisation of compartment-specific testicular macrophage populations.

Journal of reproductive immunology·2025
Same author

Electrochemical coupling at the plasma membrane by mouse voltage-sensitive phosphatase requires association with basigin.

Cell reports·2025
Same author

Galectin-1 and galectin-3 in male reproduction - impact in health and disease.

Seminars in immunopathology·2025

Related Experiment Video

Updated: Dec 4, 2025

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
11:11

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

23.2K

Immune Cell Subtypes and Their Function in the Testis.

Sudhanshu Bhushan1,2, María S Theas3,4, Vanesa A Guazzone3,4

  • 1Department of Anatomy and Cell Biology, Justus-Liebig University Giessen, Giessen, Germany.

Frontiers in Immunology
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

This review examines testicular immune cells, including macrophages, dendritic cells, T cells, and mast cells. Understanding their roles in immune privilege and inflammation is key to addressing testicular impairment.

Keywords:
T lymphocytesdendritic cellsimmune privilegemacrophagesmast cellstestis

More Related Videos

An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity
05:48

An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity

Published on: December 2, 2018

11.5K
Isolate Cell-Type-Specific RNAs from Snap-Frozen Heterogeneous Tissue Samples without Cell Sorting
08:30

Isolate Cell-Type-Specific RNAs from Snap-Frozen Heterogeneous Tissue Samples without Cell Sorting

Published on: December 8, 2021

2.4K

Related Experiment Videos

Last Updated: Dec 4, 2025

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
11:11

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

23.2K
An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity
05:48

An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity

Published on: December 2, 2018

11.5K
Isolate Cell-Type-Specific RNAs from Snap-Frozen Heterogeneous Tissue Samples without Cell Sorting
08:30

Isolate Cell-Type-Specific RNAs from Snap-Frozen Heterogeneous Tissue Samples without Cell Sorting

Published on: December 8, 2021

2.4K

Area of Science:

  • Reproductive Immunology
  • Male Reproductive System Biology
  • Immunoregulation

Background:

  • The testis maintains a unique balance between immune suppression (immune privilege) and inflammatory responses.
  • Immune cell populations within the testis dynamically alter their function between homeostatic and inflammatory states.

Purpose of the Study:

  • To review the phenotypes and functions of immune cell subtypes in the testis.
  • To elucidate how immune cell behavior changes under homeostatic versus inflammatory conditions.
  • To enhance understanding of immune-mediated testicular impairment.

Main Methods:

  • Review of existing literature on testicular immunology.
  • Analysis of immune cell phenotypes (macrophages, dendritic cells, T cells, mast cells).
  • Examination of immune cell function in both normal and inflammatory testicular environments.

Main Results:

  • Testicular macrophages are shaped by the microenvironment to ensure immune privilege.
  • Dendritic cells shift from a tolerogenic to an immunostimulatory state during inflammation.
  • Distinct populations of T cells (αβ T cells and regulatory T cells) and mast cells modulate innate immunity and immune responses.

Conclusions:

  • Immune cells in the testis, including macrophages, dendritic cells, T cells, and mast cells, play critical roles in maintaining immune privilege and responding to inflammation.
  • A deeper understanding of these cells' behavior is essential for diagnosing and managing immune-related testicular dysfunction.